Major Depressive Disorder (MDD), also known as Depression, is a mental disorder characterized by a mood of fewer than two weeks, which is present in most situations. It often happens with less self-esteem, general loss of interest in pleasant activities, less energy and pain without obvious reason. People may sometimes have false beliefs or can see or hear things that others can not do. Depression is different in some people in some people in which they are normal, while others often have symptoms almost always. The major depressive disorder can negatively impact a person's personal life, work life or education as well as sleep, eating habits and general health. Suicide occurs in 2-8% of major depressed adults, and approximately 50% of those who die of suicide have depression or other mood disorders.

The reason for this is considered a combination of genetic, environmental and psychological factors. Risk factors include a family history of the condition, major life changes, some medicines, chronic health problems and substance abuse. Approximately 40% of the risk appears to be related to genetics. The diagnosis of major depressive disorder is based on the person's reported experiences and a mental state examination. There is no laboratory test for major depression. Testing, however, can be done to exclude physical conditions that can cause similar symptoms. The major depression is more severe and lasts longer than sadness, which is a normal part of life. The United States Preventive Services Task Force (USPSTF) recommends screening for depression in people over the age of 12, whereas a former Cochrane Review found that regular use of the screening questionnaire has little effect on detection or treatment is.

Generally, people are treated with counseling and antidepressant medication. The drug appears to be effective, but the effect can only be important in the most severely depressed. It is unclear whether medicines affect the risk of suicide. The types of consultation used include cognitive behavioral therapy (CBT) and reciprocal therapy. If other remedies are not effective, electroconvulsive therapy (ECT) can be considered. In cases of suicide risk, hospitalization can be necessary and may sometimes be against a person's will.

In 2015, Major Depressive Disorder influenced approximately 216 million people (3% of the world population). The percentage of people affected at one point in their life varies from 7% in Japan to 21% in France. The rate of a lifetime is higher in the developed world (15%) than the developing world (11%). This causes the second most years of living with a disability after pain in the lower part of the back. The most common time of the beginning is in a person's 20s and 30s. Females are affected almost twice as men. In 1980, the American Psychiatric Association added "major depressive disorder" to the diagnosis of mental disorder and statistical manual (DSM-III). This was a division of the previously depressing neurosis in DSM-II, which is now included in known conditions. Dysthymia and Adjustment Disorder with Depressed Mind People currently affected or previously affected may be tarnished.

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